Squaramides represent a class of vinylogous amides that are derived from the squarate
oxocarbon dianion. While they have been known since the 1950s, squaramides have only …

In this review, we summarize the published data on squaric acid analogues with a special
focus on their use in medicinal chemistry and as potential drugs. Squaric acid is an …

Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects
people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent …

Background and Purpose We and others have shown that inhibiting phosphatase and tensin
homolog deleted on chromosome 10 (PTEN) or activating ERK1/2 confer neuroprotection …

Tacrine was the first drug to be approved for Alzheimer's disease (AD) treatment, acting as a
cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile …

Squaric acid and its derivatives are versatile synthons and have demonstrated applications
in medicinal chemistry, notably as non-classical bioisosteric replacements for functional …

Naturally occurring polyamines: putrescine, spermidine and spermine are crucial for
Kinetoplastid growth and persistence. These aliphatic polycations are either biosynthesized …

The biological and medicinal chemistry of the oxocarbon acids 2, 3-dihydroxycycloprop-2-en-
1-one (deltic acid), 3, 4-dihydroxycyclobut-3-ene-1, 2-dione (squaric acid), 4, 5-dihydroxy-4 …

Background: The authors have recently designed a new compound bisperoxovandium
(pyridin-2-squaramide)[bpV (pis)] and verified that bpV (pis) confers neuroprotection through …

Solubility is a crucial encumbrance for the synthesis of squaramides through nucleophilic
substitution of squaric acid. The reactions must be performed in an aqueous medium since …