Facing the challenges in the COVID-19 pandemic era: from standard treatments to the umbilical cord-derived mesenchymal stromal cells as a new therapeutic strategy

E Russo, S Corrao, F Di Gaudio, G Alberti, M Caprnda… - Cells, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), the pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), which counts more than 650 million cases and …

[HTML][HTML] Pulmonary fibrosis: Is stem cell therapy the way forward?

M Ikrama, M Usama, S Israr, M Humayon - Journal of Taibah University …, 2023 - Elsevier
Pulmonary fibrosis, a chronic and fatal lung disease affecting millions of people worldwide,
is characterized by the scarring of lung tissue, thereby impairing oxygen exchange between …

Mesenchymal stem cell treatment for hyperactive immune response in patients with COVID-19

R Manoharan, RA Kore, JL Mehta - Immunotherapy, 2022 - Taylor & Francis
The human immune system protects the body against invasive organisms and kicks into a
hyperactive mode in COVID-19 patients, particularly in those who are critically sick …

[HTML][HTML] Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects

M Meng, WW Zhang, SF Chen, DR Wang… - World Journal of Stem …, 2024 - ncbi.nlm.nih.gov
Pulmonary diseases across all ages threaten millions of people and have emerged as one
of the major public health issues worldwide. For diverse disease conditions, the currently …

GMP-compliant extracellular vesicles derived from umbilical cord mesenchymal stromal cells: manufacturing and pre-clinical evaluation in ARDS treatment

ZSM Costa-Ferro, GV Rocha, KN da Silva, BD Paredes… - Cytotherapy, 2024 - Elsevier
Abstract Background aims Extracellular vesicles (EVs) represent a new axis of intercellular
communication that can be harnessed for therapeutic purposes, as cell-free therapies. The …

间充质干细胞及细胞外囊泡治疗肺纤维化的现状与未来

王艳阳, 刘婵, 余丽梅, 何志旭 - 中国组织工程研究, 2024 - cjter.com
摘要背景: 尽管在临床上采取了一系列的治疗措施, 肺纤维化的治疗仍然面临着挑战.
在近年的研究中, 间充质干细胞及其细胞外囊泡作为一种新兴的治疗策略引起了广泛关注 …

GMP-compliant extracellular vesicles derived from umbilical cord mesenchymal stromal cells: manufacturing and preclinical evaluation in ARDS treatment

ZSMC Ferro, GV Rocha, KN Silva, BD Paredes… - 2024 - arca.fiocruz.br
Abstract Background aims: Extracellular vesicles (EVs) represent a new axis of intercellular
communication that can be harnessed for therapeutic purposes, as cell-free therapies. The …

Umbilical cord-derived mesenchymal stem cell transplantation for COVID-19 patients: long-term benefits for lung regeneration

NB Vu, P Van Pham - Biomedical Research and Therapy, 2022 - bmrat.com
Abstract Coronavirus disease 2019 (COVID-19) has affected hundreds of millions of people
worldwide. Currently, mortality due to COVID-19 is significantly reduced by vaccination …

Current status and future of treatment of pulmonary fibrosis by mesenchymal stem cells and extracellular vesicles

Y Wang, C Liu, L Yu, Z He - Chinese Journal of Tissue Engineering …, 2024 - cjter.com
BACKGROUND: Despite a series of clinical treatment measures, the treatment of pulmonary
fibrosis still faces challenges. In recent years, mesenchymal stem cells and their …

Product characterization and preclinical evaluation of the biodistribution and safety of umbilical cord mesenchymal stromal cell-derived extracellular vesicles

ZSM Costa-Ferro, GV Rocha, KN da Silva, BD Paredes… - 2023 - researchsquare.com
Background Extracellular vesicles (EVs) represent a new axis of intercellular communication
that can be explored for therapeutic purposes; they have garnered considerable attention for …