Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Roles for cell death in development, homeostasis, and the control of infections and cancer
have long been recognized. Although excessive cell damage results in passive necrosis …

The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …

Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized
by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a …

Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …

Caspases were originally identified as important mediators of inflammatory response and
apoptosis. Recent discoveries, however, have unveiled their roles in mediating and …

Intestinal epithelial cells (IEC) are organised as a single cell layer which covers the intestine.
Their primary task is to absorb nutrients present in the intestinal lumen. However, IEC also …

RIPK1 and RIPK3 (receptor-interacting serine/threonine protein kinases 1/3) interact by
virtue of their RIP homotypic interaction motifs to mediate a form of cell death called …

Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …