The p53 gene contains homozygous mutations in~ 50–60% of human cancers. About 90%
of these mutations encode missense mutant proteins that span~ 190 different codons …

The pathogenesisrelated (PR) proteins of plants have originally been identified as proteins
that are strongly induced upon biotic and abiotic stress. These proteins fall into 17 distinct …

The ConSurf websever for the analysis of proteins, RNA, and DNA provides a quick and
accurate estimate of the persite evolutionary rate among homologues. The analysis reveals …

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgEmediated allergies has …

Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …

Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR
releases intracellular molecules known as damage-associated molecular patterns (DAMPs) …

DNA sequencing-based studies of neurodevelopmental disorders (NDDs) have identified a
wide range of genetic determinants. However, a comprehensive analysis of these data, in …

Coronaviruses (CoVs) traffic frequently between species resulting in novel disease
outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, the causative …

Bacteria have evolved diverse immunity mechanisms to protect themselves against the
constant onslaught of bacteriophages,–. Similar to how eukaryotic innate immune systems …

The dynamic ribosome–translocon complex, which resides at the endoplasmic reticulum
(ER) membrane, produces a major fraction of the human proteome,. It governs the synthesis …