Abstract The inositol 1, 4, 5-trisphosphate (IP 3) receptor (IP 3 R) is a Ca 2+-release channel
mainly located in the endoplasmic reticulum (ER). Three IP 3 R isoforms are responsible for …

Apoptosis is a highly complex and regulated cell death pathway that safeguards the
physiological balance between life and death. Over the past decade, the role of Ca 2+ …

Oscillations in the concentration of free cytosolic Ca2+ are an important and ubiquitous
control mechanism in many cell types. It is thus correspondingly important to understand the …

Bok is a member of the Bcl-2 protein family that governs the intrinsic apoptosis pathway,
although the role that Bok plays in this pathway is unclear. We have shown previously in …

Over the last years, the experimental compound olesoxime, a mitochondria-targeting
cholesterol derivative, has emerged as a promising drug candidate for neurodegenerative …

Excessive rapid increases in cytosolic free Ca2+ have a clear association with the induction
of cancer cell death. Whereas, characterizing the Ca2+ signaling events that occur during …

The spatio-temporal behaviour of the intracellular calcium concentration is both
physiologically important and theoretically complex, and this has led to a large body of joint …

The increase in hypoxia events, a result of climate change in coastal and fjord ecosystems,
impacts the health and survival of mussels. These organisms deploy physiological and …

Local and privileged expression of dendritic proteins allows segregation of distinct functions
in a single neuron but may represent one of the underlying mechanisms for early and …

Ion channels are pore-forming protein complexes in membranes that play essential roles in
a diverse array of biological activities. Ion channel activity is strictly regulated at multiple …