Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers

AC Tsai, R Jeske, X Chen, X Yuan, Y Li - Frontiers in bioengineering …, 2020 - frontiersin.org
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …

Disposable rocking bioreactors: recent applications and progressive perspectives

K Wierzchowski, M Pilarek - Trends in Biotechnology, 2024 - cell.com
Disposable rocking bioreactors facilitate scaling up animal and plant cell biomass
propagation and developing specified bioprocesses like manufacturing vaccines or chimeric …

Single-use bioreactors for human pluripotent and adult stem cells: towards regenerative medicine applications

DES Nogueira, JMS Cabral, CAV Rodrigues - Bioengineering, 2021 - mdpi.com
Research on human stem cells, such as pluripotent stem cells and mesenchymal stromal
cells, has shown much promise in their use for regenerative medicine approaches …

Bioprocessing of human mesenchymal stem cells: From planar culture to microcarrier-based bioreactors

AC Tsai, CA Pacak - Bioengineering, 2021 - mdpi.com
Human mesenchymal stem cells (hMSCs) have demonstrated great potential to be used as
therapies for many types of diseases. Due to their immunoprivileged status, allogeneic …

An insight on the advancements of biological technologies in the bioremediation of textile effluents

S Reddy, J Osborne - Urban Water Journal, 2022 - Taylor & Francis
Advances in textile processing technologies and industrial growth has made textile
industries as a major source of water pollution. Increasing pollution and shrinking freshwater …

Culture substrates for improved manufacture of mesenchymal stromal cell therapies

G Doron, JS Temenoff - Advanced Healthcare Materials, 2021 - Wiley Online Library
Recent developments in mesenchymal stromal cell (MSC) therapies have increased the
demand for tools to improve their manufacture, including the selection of optimal culture …

Transcriptomic profiling of human mesenchymal stem cells using a pulsed electromagnetic-wave motion bioreactor system for enhanced osteogenic commitment and …

A Randhawa, K Ganguly, SD Dutta, TV Patil, KT Lim - Biomaterials, 2025 - Elsevier
Traditional bioreactor systems involve the use of three-dimensional (3D) scaffolds or stem
cell aggregates, limiting the accessibility to the production of cell-secreted biomolecules …

Mapping the microcarrier design pathway to modernise clinical mesenchymal stromal cell expansion

GS Major, VK Doan, A Longoni, MMM Bilek… - Trends in …, 2024 - cell.com
Microcarrier expansion systems show exciting potential to revolutionise mesenchymal
stromal cell (MSC)-based clinical therapies by providing an opportunity for economical large …

[HTML][HTML] Mass transfer characteristics in disposable rocking bioreactors: A critical review and quantitative data catalogue

K Wierzchowski, M Pilarek - Chemical Engineering Journal, 2024 - Elsevier
Disposable rocking bioreactors allow for efficient surface aeration of culture medium via 1D,
2D, or 3D oscillatory movements, as opposed to traditional bioreactors equipped with an …

[HTML][HTML] Advances in human mesenchymal stromal cell-based therapies–Towards an integrated biological and engineering approach

TA Wyrobnik, A Ducci, M Micheletti - Stem Cell Research, 2020 - Elsevier
Recent advances of stem cell-based therapies in clinical trials have raised the need for large-
scale manufacturing platforms that can supply clinically relevant doses to meet an …