Trypsin inhibitors: promising candidate satietogenic proteins as complementary treatment for obesity and metabolic disorders?

V Cristina Oliveira de Lima, G Piuvezam… - Journal of enzyme …, 2019 - Taylor & Francis
The increase in non-communicable chronic diseases has aroused interest in the research of
adjuvants to the classic forms of treatments. Obesity and metabolic syndrome are the main …

Tamarind Enzymatic Inhibitors: Activities and Health Application Perspectives

F Carvalho, BLL Maciel, A Morais - Food Reviews International, 2022 - Taylor & Francis
Tamarind is a fruit with a wide variety of uses, and the presence of enzyme inhibitors in
Tamarind seeds gives the fruit bioactive activities. Protease inhibitors have been recognized …

Tamarind trypsin inhibitor in chitosan–whey protein nanoparticles reduces fasting blood glucose levels without compromising insulinemia: A preclinical study

LLR Matias, ROA Costa, TS Passos, JLC Queiroz… - Nutrients, 2019 - mdpi.com
In vivo studies show the benefits of the trypsin inhibitor isolated from tamarind
(Tamarindusindica L.)(TTI) seeds in satiety and obesity. In the present study, TTI …

An Insulin Receptor-Binding Multifunctional Protein from Tamarindus indica L. Presents a Hypoglycemic Effect in a Diet-Induced Type 2 Diabetes—Preclinical Study

I Costa, M Lima, A Medeiros, L Bezerra, P Santos… - Foods, 2022 - mdpi.com
The objectives of this study were to evaluate the hypoglycemic effect of the trypsin inhibitor
isolated from tamarind seeds (TTI) in an experimental model of T2DM and the in silico …

Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ …

FMC Carvalho, VCO Lima, IS Costa, ABS Luz… - Nutrients, 2019 - mdpi.com
The increasing prevalence of obesity and, consequently, chronic inflammation and its
complications has increased the search for new treatment methods. The effect of the purified …

Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from Tamarindus indica L

AF de Medeiros, BBP de Souza… - Journal of Enzyme …, 2021 - Taylor & Francis
Trypsin inhibitors from tamarind seed have been studied in vitro and in preclinical studies for
the treatment of obesity, its complications and associated comorbidities. It is still necessary …

[HTML][HTML] Safety and potential functionality of nanoparticles loaded with a trypsin inhibitor isolated from tamarind seeds

RO de Araújo Costa, LLR Matias, TS Passos… - Future Foods, 2020 - Elsevier
The trypsin inhibitor isolated from tamarind seeds (TTI) presents satietogenic and anti-
inflammatory effects. In the present study, TTI encapsulation by nanoprecipitation in purified …

Beneficial effects of tamarind trypsin inhibitor in chitosan–whey protein nanoparticles on hepatic injury induced high glycemic index diet: a preclinical study

AJFC Aguiar, JLC de Queiroz, PPA Santos… - International Journal of …, 2021 - mdpi.com
Several studies have sought new therapies for obesity and liver diseases. This study
investigated the effect of the trypsin inhibitor isolated from tamarind seeds (TTI) …

[HTML][HTML] Tamarind multifunctional protein: Safety and anti-inflammatory potential in intestinal mucosa and adipose tissue in a preclinical model of diet-induced obesity

VCO Lima, A Luz, MSM Amarante, MCJS Lima… - Obesity Facts, 2021 - karger.com
Introduction: Obesity has emerged as one of the main public health problems. This condition
triggers a series of hormonal and metabolic changes related to a low-grade chronic …

Prospecting in silico antibacterial activity of a peptide from trypsin inhibitor isolated from tamarind seed

GS Oliveira, AMS Nascimento, ABS Luz… - Journal of Enzyme …, 2023 - Taylor & Francis
Bacterial infections have become a global concern, stimulating the growing demand for
natural and biologically safe therapeutic agents with antibacterial action. This study was …