Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in
the literature, there is still confusion regarding its pathogenesis and clinical significance …

Eosinophils are a prominent cell type in particular host responses such as the response to
helminth infection and allergic disease. Their effector functions have been attributed to their …

Cancer cell dissemination during very early stages of breast cancer proceeds through poorly
understood mechanisms. Here we show, in a mouse model of HER2+ breast cancer, that a …

The intestine harbors a large population of resident eosinophils, yet the function of intestinal
eosinophils has not been explored. Flow cytometry and whole-mount imaging identified …

Tissue-resident macrophages adapt to local signals within tissues to acquire specific
functions. Neoplasia transforms the tissue, raising the question as to how the environmental …

Evidence from clinical and experimental studies indicates that macrophages promote solid-
tumour progression and metastasis. Macrophages are educated by the tumour …

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly
supplanting long-established traditional cell lines as preferred models for conducting basic …

Specialized phagocytes are found in the most primitive multicellular organisms. Their roles
in homeostasis and in distinguishing self from non-self have evolved with the complexity of …

Breast cancer research is hampered by difficulties in obtaining and studying primary human
breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology …