The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant
physiological and pharmacological effects. In this review we summarize data from numerous …

ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential
(TRP) channels that are activated by changes in the environmental temperature, from …

TRPM8 is a cold sensor that is highly expressed in the prostate as well as in other non-
temperature-sensing organs, and is regulated by downstream receptor–activated signaling …

The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary
somatosensory neurons termed nociceptors. The molecular receptors of noxious …

Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue.
Shortly thereafter, the protein was identified as a cold-and menthol-activated ion channel in …

The Ca2+ signal has major roles in cellular processes important in tumorigenesis, including
migration, invasion, proliferation, and apoptotic sensitivity. New evidence has revealed that …

The members of transient receptor potential (TRP) superfamily of cationic ion channels
represent universal sensors, which convert multiple exogenous and endogenous chemical …

Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the
development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests …

TRP channels are expressed both in vascular myocytes and endothelial cells, but
knowledge of their operational mechanisms in vascular tissue is particularly limited. Here …