Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Bile acids are signaling molecules that coordinately regulate metabolism and inflammation
via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …

Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs)
are notable for the fact that they were hiding in plain sight. BAs were well known for their …

In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …

Avermectins are a group of drugs that occurs naturally as a product of fermenting
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …

Bile acids (BAs) are cholesterol-derived metabolites that facilitate the intestinal absorption
and transport of dietary lipids. Recently, BAs also emerged as pivotal signaling molecules …

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

The human gut microbiota impacts host metabolism and has been implicated in the
pathophysiology of obesity and metabolic syndromes. However, defining the roles of specific …

The liver is the central metabolic hub which coordinates nutritional inputs and metabolic
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …

Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …