Background Growing evidence associates organ dysfunction (s) with impaired metabolism
in sepsis. Recent research has increased our understanding of the role of substrate …

The vascular endothelial glycocalyx is a dense, bush-like structure that is synthesized and
secreted by endothelial cells and evenly distributed on the surface of vascular endothelial …

Background & Aims Even after recovery from overt hepatic encephalopathy (HE), minimal
HE (MHE), which impairs quality of life (QoL), can persist. A double-blind, placebo-controlled …

Preclinical studies in animals and human clinical trials question whether the endothelial
glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown …

Cardiogenic shock is usually defined as primary cardiac dysfunction with low cardiac output
leading to critical organ hypoperfusion, and tissue hypoxia, resulting in high mortality rate …

Background Fluid therapy is a cornerstone in the treatment of sepsis. Recently, the
guidelines have recommended the combined administration that using crystalloids plus …

The glycocalyx is a complex polysaccharide-protein layer lining the lumen of vascular
endothelial cells. Changes in the structure and function of the glycocalyx promote an …

The glycocalyx surrounds every eukaryotic cell and is a complex mesh of proteins and
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …

COVID-19 is a highly infectious respiratory disease caused by a new coronavirus known as
SARS-CoV-2. COVID-19 is characterized by progressive respiratory failure resulting from …

The endothelial glycocalyx is a negatively charged, carbohydrate-rich structure that arises
from the luminal surface of the vascular endothelium and is comprised of proteoglycans …