Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …

There is an unmet need for high‐quality liquid biomarkers that can safely and reproducibly
predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The …

Articular cartilage is a connective tissue consisting of a specialized extracellular matrix
(ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are …

Several collagen subtypes have been identified in hyaline articular cartilage. The main and
most abundant collagens are type II, IX and XI collagens. The minor and less abundant …

Knee osteoarthritis (KOA) is the most common form of joint degeneration with increasing
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …

Osteoarthritis (OA) is a degenerative disease of the joints and is one of the leading causes of
disability in adults. However, there are no key therapeutics for OA and medical treatment is …

Objective To review and summarize biomarker data published from April 2014 to May 2015
to provide insight to the ongoing work in the field of osteoarthritis (OA). Furthermore, to …

The association between structural changes and pain sensation in osteoarthritis (OA)
remains unclear. Joint deterioration in OA leads to the release of protein fragments that can …

It is currently understood that osteoarthritis (OA) is a major chronic inflammatory
musculoskeletal disease. While this disease has long been attributed to biomechanical …

In recent years, markers research has focused on the structural components of cartilage
matrix. Specifically, a second generation of degradation markers has been developed …