[HTML][HTML] CD44: a multifunctional mediator of cancer progression
CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …
[HTML][HTML] The hnRNP family: insights into their role in health and disease
T Geuens, D Bouhy, V Timmerman - Human genetics, 2016 - Springer
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-
binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism …
binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism …
[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
[HTML][HTML] m6A readers, writers, erasers, and the m6A epitranscriptome in breast cancer
Epitranscriptomic modification of RNA regulates human development, health, and disease.
The true diversity of the transcriptome in breast cancer including chemical modification of …
The true diversity of the transcriptome in breast cancer including chemical modification of …
[HTML][HTML] The application of Aptamer in biomarker discovery
Y Li, WW Tam, Y Yu, Z Zhuo, Z Xue, C Tsang, X Qiao… - Biomarker …, 2023 - Springer
Biomarkers are detectable molecules that can reflect specific physiological states of cells,
organs, and organisms and therefore be regarded as indicators for specific diseases. And …
organs, and organisms and therefore be regarded as indicators for specific diseases. And …
A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA
L Siculella, L Giannotti, B Di Chiara Stanca… - Cancer gene …, 2023 - nature.com
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is the most abundant and
ubiquitously expressed member of the heterogeneous nuclear ribonucleoproteins family …
ubiquitously expressed member of the heterogeneous nuclear ribonucleoproteins family …
Cancer-associated MORC2-mutant M276I regulates an hnRNPM-mediated CD44 splicing switch to promote invasion and metastasis in triple-negative breast cancer
FL Zhang, JL Cao, HY Xie, R Sun, LF Yang, ZM Shao… - Cancer research, 2018 - AACR
Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with a high
propensity for distant metastasis and limited treatment options, yet its molecular …
propensity for distant metastasis and limited treatment options, yet its molecular …
Emerging roles of hnRNPA1 in modulating malignant transformation
R Roy, Y Huang, MJ Seckl… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA‐binding proteins associated
with complex and diverse biological processes such as processing of heterogeneous …
with complex and diverse biological processes such as processing of heterogeneous …
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma
BR Muys, DG Anastasakis, D Claypool… - Genes & …, 2021 - genesdev.cshlp.org
Abstract p53 is an intensely studied tumor-suppressive transcription factor. Recent studies
suggest that the RNA-binding protein (RBP) ZMAT3 is important in mediating the tumor …
suggest that the RNA-binding protein (RBP) ZMAT3 is important in mediating the tumor …
[HTML][HTML] Therapeutic targeting of RNA splicing in cancer
EA Bonner, SC Lee - Genes, 2023 - mdpi.com
RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly
dynamic process orchestrated by the spliceosome, a macro-molecular machinery that …
dynamic process orchestrated by the spliceosome, a macro-molecular machinery that …