[HTML][HTML] CD44: a multifunctional mediator of cancer progression

M Hassn Mesrati, SE Syafruddin, MA Mohtar, A Syahir - Biomolecules, 2021 - mdpi.com
CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

[HTML][HTML] The hnRNP family: insights into their role in health and disease

T Geuens, D Bouhy, V Timmerman - Human genetics, 2016 - Springer
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-
binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism …

[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer

M Mehta, R Raguraman, R Ramesh… - Advanced drug delivery …, 2022 - Elsevier
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

[HTML][HTML] m6A readers, writers, erasers, and the m6A epitranscriptome in breast cancer

BJ Petri, CM Klinge - Journal of molecular endocrinology, 2023 - jme.bioscientifica.com
Epitranscriptomic modification of RNA regulates human development, health, and disease.
The true diversity of the transcriptome in breast cancer including chemical modification of …

[HTML][HTML] The application of Aptamer in biomarker discovery

Y Li, WW Tam, Y Yu, Z Zhuo, Z Xue, C Tsang, X Qiao… - Biomarker …, 2023 - Springer
Biomarkers are detectable molecules that can reflect specific physiological states of cells,
organs, and organisms and therefore be regarded as indicators for specific diseases. And …

A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA

L Siculella, L Giannotti, B Di Chiara Stanca… - Cancer gene …, 2023 - nature.com
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is the most abundant and
ubiquitously expressed member of the heterogeneous nuclear ribonucleoproteins family …

Cancer-associated MORC2-mutant M276I regulates an hnRNPM-mediated CD44 splicing switch to promote invasion and metastasis in triple-negative breast cancer

FL Zhang, JL Cao, HY Xie, R Sun, LF Yang, ZM Shao… - Cancer research, 2018 - AACR
Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with a high
propensity for distant metastasis and limited treatment options, yet its molecular …

Emerging roles of hnRNPA1 in modulating malignant transformation

R Roy, Y Huang, MJ Seckl… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA‐binding proteins associated
with complex and diverse biological processes such as processing of heterogeneous …

The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma

BR Muys, DG Anastasakis, D Claypool… - Genes & …, 2021 - genesdev.cshlp.org
Abstract p53 is an intensely studied tumor-suppressive transcription factor. Recent studies
suggest that the RNA-binding protein (RBP) ZMAT3 is important in mediating the tumor …

[HTML][HTML] Therapeutic targeting of RNA splicing in cancer

EA Bonner, SC Lee - Genes, 2023 - mdpi.com
RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly
dynamic process orchestrated by the spliceosome, a macro-molecular machinery that …