Neurotrophin signal transduction by the Trk receptor
DR Kaplan, RM Stephens - Journal of neurobiology, 1994 - Wiley Online Library
The initial event in the neuronal differentiation of PC12 cells is the binding of the
neurotrophin nerve growth factor (NGF) to the Trk receptor. This interaction stimulates the …
neurotrophin nerve growth factor (NGF) to the Trk receptor. This interaction stimulates the …
Protein kinase C (PKC) isozyme-specific substrates and their design
Protein kinase C (PKC), a phospholipid-dependent serine/threonine kinase, appears to be
involved in the signal transduction response to many hormones and growth factors; there …
involved in the signal transduction response to many hormones and growth factors; there …
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor
H Ishii, MR Jirousek, D Koya, C Takagi, P Xia… - Science, 1996 - science.org
The vascular complications of diabetes mellitus have been correlated with enhanced
activation of protein kinase C (PKC). LY333531, a specific inhibitor of the β isoform of PKC …
activation of protein kinase C (PKC). LY333531, a specific inhibitor of the β isoform of PKC …
Vascular endothelial growth factor–induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform–selective …
Increased vascular permeability and excessive neovas-cularization are the hallmarks of
endothelial dysfunction, which can lead to diabetic macular edema and proliferative diabetic …
endothelial dysfunction, which can lead to diabetic macular edema and proliferative diabetic …
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and …
D Koya, MR Jirousek, YW Lin, H Ishii… - The Journal of …, 1997 - Am Soc Clin Investig
Induction of protein kinase C (PKC) pathway in the vascular tissues by hyperglycemia has
been associated with many of the cellular changes observed in the complications of …
been associated with many of the cellular changes observed in the complications of …
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.
Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen which
mediates its effects by binding to tyrosine kinase receptors. We have characterized the …
mediates its effects by binding to tyrosine kinase receptors. We have characterized the …
High glucose concentrations increase endothelial cell permeability via activation of protein kinase Cα
A Hempel, C Maasch, U Heintze, C Lindschau… - Circulation …, 1997 - Am Heart Assoc
Endothelial cell permeability is impaired in diabetes mellitus and may be increased by high
extracellular glucose concentrations. High glucose activates protein kinase C (PKC), a …
extracellular glucose concentrations. High glucose activates protein kinase C (PKC), a …
ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.
JW Haycock, NG Ahn, MH Cobb… - Proceedings of the …, 1992 - National Acad Sciences
Tyrosine hydroxylase (TH) is phosphorylated at four sites in situ and in vivo, and the protein
kinases that phosphorylate three of these sites (Ser8, Ser19, Ser40) have been identified. In …
kinases that phosphorylate three of these sites (Ser8, Ser19, Ser40) have been identified. In …
Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells: Identity with the mitogen‐activated MAP …
Y Gotoh, E Nishida, T Yamashita… - European journal of …, 1990 - Wiley Online Library
Treatment of PC12 cells with either nerve growth factor (NGF), a differentiating factor, or
epidermal growth factor (EGF), a mitogen, resulted in 7–15‐fold activation of a protein …
epidermal growth factor (EGF), a mitogen, resulted in 7–15‐fold activation of a protein …
[HTML][HTML] The 38-amino acid form of pituitary adenylate cyclase-activating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neurite …
PJ Deutsch, Y Sun - Journal of Biological Chemistry, 1992 - Elsevier
Vasoactive intestinal peptide (VIP) activates adenylylcyclase in sympathoadrenal cells at
concentrations greater than 10 (-6) M. We demonstrate here that two forms of a newly …
concentrations greater than 10 (-6) M. We demonstrate here that two forms of a newly …