Mechanisms and therapeutic strategies for non‐T2 asthma

E Sze, A Bhalla, P Nair - Allergy, 2020 - Wiley Online Library
Non‐T2 asthma is traditionally defined as asthma without features of T2 asthma. The
definition is arbitrary and is generally based on the presence of neutrophils in sputum, or the …

[HTML][HTML] Biomimetic nanoparticles for inflammation targeting

K Jin, Z Luo, B Zhang, Z Pang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
There have been many recent exciting developments in biomimetic nanoparticles for
biomedical applications. Inflammation, a protective response involving immune cells, blood …

Neutrophils in periodontal inflammation

DA Scott, J Krauss - Periodontal disease, 2012 - karger.com
Neutrophils (also called polymorphonuclear leukocytes) are the most abundant leukocytes
whose primary purpose as anti-microbial professional phagocytes is to kill extracellular …

[HTML][HTML] Molecular mechanisms of lidocaine

R Karnina, SK Arif, M Hatta, A Bukhari - Annals of medicine and surgery, 2021 - Elsevier
Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations.
Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory …

Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis

JD Chalmers, AT Hill - Molecular immunology, 2013 - Elsevier
Bronchiectasis is a chronic inflammatory lung disease. The underlying cause is not identified
in the majority of patients, but bronchiectasis is associated with a number of severe …

S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal‐regulated kinase and nuclear factor‐κB pathways

JH Kang, SM Hwang, IY Chung - Immunology, 2015 - Wiley Online Library
Airway mucus hyperproduction is a common feature of chronic airway diseases such as
severe asthma, chronic obstructive pulmonary disease and cystic fibrosis, which are closely …

Viscoelastic properties of differentiating blood cells are fate-and function-dependent

AE Ekpenyong, G Whyte, K Chalut, S Pagliara… - 2012 - journals.plos.org
Although cellular mechanical properties are known to alter during stem cell differentiation,
understanding of the functional relevance of such alterations is incomplete. Here, we show …

Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study

D Singh, L Edwards, R Tal-Singer, S Rennard - Respiratory research, 2010 - Springer
Introduction The percentage of neutrophils in sputum are increased in COPD patients, and
may therefore be a biomarker of airway inflammation. We studied the relationships between …

Pathological roles of neutrophil‐mediated inflammation in asthma and its potential for therapy as a target

H Gao, S Ying, Y Dai - Journal of immunology research, 2017 - Wiley Online Library
Asthma is a chronic inflammatory disease that undermines the airways. It is caused by
dysfunction of various types of cells, as well as cellular components, and is characterized by …

The molecular mechanisms of glucocorticoids-mediated neutrophil survival

AS Saffar, H Ashdown, AS Gounni - Current drug targets, 2011 - ingentaconnect.com
Neutrophil-dominated inflammation plays an important role in many airway diseases
including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic …