Kinases have emerged as one of the most intensively pursued targets in current
pharmacological research, especially for cancer, due to their critical roles in cellular …

The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …

Highlights•A dramatic increase in the approval of small molecule kinase inhibitors
(SMKIs).•The molecular weight of most approved SMKIs is in the range of 400–600.•The …

The identification of driver oncogenes has provided important targets for drugs that can
change the landscape of cancer therapies. One such example is the BRAF oncogene, which …

The ATP site of kinases displays remarkable conformational flexibility when accommodating
chemically diverse small molecule inhibitors. The so-called activation segment, whose …

Small-molecule kinase inhibitors are invaluable targeted therapeutics for the treatment of
various human diseases, especially cancers. While the majority of approved and developed …

Tyrosine Kinase Inhibitors - StatPearls - NCBI Bookshelf US flag An official website of the
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There are over 500 human kinases ranging from very well-studied to almost completely
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …

Multiple kinases play a critical role in orchestrating the chronic inflammation and structural
changes in the respiratory tract of patients with asthma and chronic obstructive pulmonary …

The fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases has been
implicated in a wide variety of cancers. Despite a high level of sequence homology in the …