Currently, humans are immersed in a pandemic caused by the emerging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health …

Proteolytic cleavage regulates numerous processes in health and disease. One key player
is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at …

The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …

In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus
Disease COVID-19), due to a new Coronavirus strain (ie, SARS-CoV-2), emerged in the …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a
challenge to global health. At present, many candidate small-molecule therapeutics have …

Furin is the first discovered proprotein convertase member and is present in almost all
mammalian cells. Therefore, by regulating the maturation of a wide range of proproteins …

The COVID-19 pandemic is an urgent global health emergency, and the presence of Furin
site in the SARS-CoV-2 spike glycoprotein alters virulence and warrants further molecular …

Entrance of coronavirus into cells happens through the spike proteins on the virus surface,
for which the spike protein should be cleaved into S1 and S2 domains. This cleavage is …

With the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002, the middle
east respiratory syndrome CoV (MERS-CoV) in 2012 and the recently discovered SARS …