COVID-19: drug targets and potential treatments
C Gil, T Ginex, I Maestro, V Nozal… - Journal of medicinal …, 2020 - ACS Publications
Currently, humans are immersed in a pandemic caused by the emerging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health …
respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health …
Furin‐mediated protein processing in infectious diseases and cancer
E Braun, D Sauter - Clinical & translational immunology, 2019 - Wiley Online Library
Proteolytic cleavage regulates numerous processes in health and disease. One key player
is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at …
is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at …
Oral antiviral treatments for COVID-19: opportunities and challenges
L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …
and prevent disease progression to a more severe form. However, the timing of antiviral …
Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches
M Gioia, C Ciaccio, P Calligari, G De Simone… - Biochemical …, 2020 - Elsevier
In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus
Disease COVID-19), due to a new Coronavirus strain (ie, SARS-CoV-2), emerged in the …
Disease COVID-19), due to a new Coronavirus strain (ie, SARS-CoV-2), emerged in the …
Proteolytic Cleavage Mechanisms, Function, and “Omic” Approaches for a Near-Ubiquitous Posttranslational Modification
Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …
widespread, irreversible posttranslational modification of the protein's structure and …
[HTML][HTML] An update review of emerging small-molecule therapeutic options for COVID-19
D Tian, Y Liu, C Liang, L Xin, X Xie, D Zhang… - Biomedicine & …, 2021 - Elsevier
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a
challenge to global health. At present, many candidate small-molecule therapeutics have …
challenge to global health. At present, many candidate small-molecule therapeutics have …
The proprotein convertase furin in cancer: More than an oncogene
Z He, AM Khatib, JWM Creemers - Oncogene, 2022 - nature.com
Furin is the first discovered proprotein convertase member and is present in almost all
mammalian cells. Therefore, by regulating the maturation of a wide range of proproteins …
mammalian cells. Therefore, by regulating the maturation of a wide range of proproteins …
Structure of furin protease binding to SARS-CoV-2 spike glycoprotein and implications for potential targets and virulence
N Vankadari - The journal of physical chemistry letters, 2020 - ACS Publications
The COVID-19 pandemic is an urgent global health emergency, and the presence of Furin
site in the SARS-CoV-2 spike glycoprotein alters virulence and warrants further molecular …
site in the SARS-CoV-2 spike glycoprotein alters virulence and warrants further molecular …
The role of folic acid in the management of respiratory disease caused by COVID-19
Z Sheybani, MH Dokoohaki, M Negahdaripour… - 2020 - chemrxiv.org
Entrance of coronavirus into cells happens through the spike proteins on the virus surface,
for which the spike protein should be cleaved into S1 and S2 domains. This cleavage is …
for which the spike protein should be cleaved into S1 and S2 domains. This cleavage is …
[HTML][HTML] Nanomedicine strategies to target coronavirus
With the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002, the middle
east respiratory syndrome CoV (MERS-CoV) in 2012 and the recently discovered SARS …
east respiratory syndrome CoV (MERS-CoV) in 2012 and the recently discovered SARS …