Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well
established for the treatment of malaria, including highly drug-resistant strains. Their efficacy …

The artemisinin (ART)-based antimalarials have contributed significantly to reducing global
malaria deaths over the past decade, but we still do not know how they kill parasites. To gain …

The growing resistance to current first-line antimalarial drugs represents a major health
challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient …

Malarial dihydrofolate reductase (DHFR) is the target of antifolate antimalarial drugs such as
pyrimethamine and cycloguanil, the clinical efficacy of which have been compromised by …

Despite intensive research extending back to the 1930s, when the first synthetic antimalarial
drugs made their appearance, the repertoire of clinically licensed formulations remains very …

The spread of high-level pyrimethamine resistance in Africa threatens to curtail the
therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary …

Chemotherapy remains the most important means of controlling malaria, one of the
deadliest infectious parasitic diseases in the world. Antimalarial antifolates have been …

Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

Synthesis de novo, acquisition by salvage and interconversion of purines and pyrimidines
represent the fundamental requirements for their eventual assembly into nucleic acids as …