Human skin forms a protective barrier against the external environment and is our first line of
defense against toxic, solar, and pathogenic insults. Our skin also defines our outward …

The coagulase-negative bacterium Staphylococcus epidermidis is a member of the human
skin microbiota. S. epidermidis is not merely a passive resident on skin but actively primes …

Human skin is the largest organ and serves as the first line of defense against environmental
factors. The human microbiota is defined as the total microbial community that coexists in the …

As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …

The human fetal immune system begins to develop early during gestation; however, factors
responsible for fetal immune-priming remain elusive. We explored potential exposure to …

Humans and their microbiota have coevolved a mutually beneficial relationship in which the
human host provides a hospitable environment for the microorganisms and the microbiota …

The epidermis forms a barrier that defends the body from desiccation and entry of harmful
substances, while also sensing and integrating environmental signals. The tightly …

Psoriasis is a chronic inflammatory disease with a strong genetic component that can be
triggered by environmental factors. Disease pathogenesis is mainly driven by type 1 and …

abstract The skin microbiome is a key component of pathogenesis in atopic dermatitis (AD).
The skin of AD patients is characterized by microbial dysbiosis, with a reduction of microbial …