It is proposed that the multiple enhancer elements associated with locus control regions and
super‐enhancers recruit RNA polymerase II and efficiently assemble elongation competent …

Pluripotent stem cells of the mammalian epiblast and their cultured counterparts—embryonic
stem cells (ESCs) and epiblast stem cells (EpiSCs)—have the capacity to differentiate in all …

Silencing of the somatic cell type-specific genes is a critical yet poorly understood step in
reprogramming. To uncover pathways that maintain cell identity, we performed a …

Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental
changes in the early embryo. PSCs can be stabilized in the naive state by blocking …

Cell fate decision involves rewiring of the genome, but remains poorly understood at the
chromatin level. Here, we report that chromatin remodeling complex NuRD participates in …

The main viral protease (3CL pro) is indispensable for SARS-CoV-2 replication. We
delineate the human protein substrate landscape of 3CL pro by TAILS substrate-targeted N …

The objective of this study was to reveal the mechanism underlying the effects of microwave
treatment on Tartary buckwheat germination and flavonoids enrichment. Label-free …

Long-range regulation by distal enhancers plays critical roles in cell-type specific
transcriptional programs. Computational predictions of genome-wide enhancer–promoter …

The establishment and maintenance of cellular identity are crucial during development and
tissue homeostasis. Epigenetic mechanisms based largely on DNA methylation and histone …

Abstract seRNA is a noncoding RNA (ncRNA) transcribed from active super-enhancer (SE),
through which SE exerts biological functions and participates in various physiological and …