The localization and control of Bcl-2 proteins on mitochondria is essential for the intrinsic
pathway of apoptosis. Anti-apoptotic Bcl-2 proteins reside on the outer mitochondrial …

A group of integral membrane proteins, known as C-tail anchored, is defined by the
presence of a cytosolic NH2-terminal domain that is anchored to the phospholipid bilayer by …

In the mitochondrial outer membrane, α-helical transmembrane proteins play critical roles in
cytoplasmic-mitochondrial communication. Using genome-wide CRISPR screens, we …

Starvation-induced autophagosomes engulf cytosol and/or organelles and deliver them to
lysosomes for degradation, thereby resupplying depleted nutrients. Despite advances in …

In eukaryotic cells, different organelles interact at membrane contact sites stabilized by
tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an …

Summary Tail-anchored (TA) proteins, defined by the presence of a single C-terminal
transmembrane domain (TMD), play critical roles throughout the secretory pathway and in …

Two human Fzo-homologs, mitofusins Mfn1 and Mfn2, are shown by RT-PCR and western
blot to be ubiquitous mitochondrial proteins. Protease digestion experiments reveal that …

Hundreds of proteins are anchored in intracellular membranes by a single transmembrane
domain (TMD) close to the C terminus. Although these tail-anchored (TA) proteins serve …

The endoplasmic reticulum (ER) can transform from a network of branching tubules into
stacked membrane arrays (termed organized smooth ER [OSER]) in response to elevated …

A large group of diverse, functionally important, and differently localized transmembrane
proteins, share a particular membrane topology, consisting of a cytosolic N-terminal region …