Neurons have diverse molecular, morphological, connectional and functional properties. We
believe that the only realistic way to manage this complexity—and thereby pave the way for …

Tremendous progress has been made since Neuron published our Primer on genetic
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …

Amacrine cells (ACs) are a diverse class of interneurons that modulate input from
photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively …

Genetically encoded voltage indicators are emerging tools for monitoring voltage dynamics
with cell-type specificity. However, current indicators enable a narrow range of applications …

The vertebrate retina first evolved some 500 million years ago in ancestral marine
chordates. Since then, the eyes of different species have been tuned to best support their …

Classification and characterization of neuronal types are critical for understanding their
function and dysfunction. Neuronal classification schemes typically rely on measurements of …

To understand the function of cortical circuits, it is necessary to catalog their cellular
diversity. Past attempts to do so using anatomical, physiological or molecular features of …

GABAergic interneurons, which are highly diverse, have long been thought to contribute to
the timing of neural activity as well as to the generation and shaping of brain rhythms …

For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …