Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …

The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …

The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …

Circadian misalignment, such as in shift work, has been associated with obesity and type 2
diabetes. However, direct effects of circadian misalignment on skeletal muscle insulin …

Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of
obesity and T2D is significantly higher in shift workers compared to people working regular …

Energy metabolism is tightly linked with circadian rhythms, exposure to ambient light,
sleep/wake, fasting/eating, and rest/activity cycles. External factors, such as shift work, lead …

Glucose tolerance is lower at night and higher in the morning. Shift workers, who often eat at
night and experience circadian misalignment (ie misalignment between the central circadian …

In the context of neurodegenerative disorders, cognitive decline is frequently reported in
older population. Recently, numerous metabolic pathways have been implicated in …

The generation of pancreatic cell types from renewable cell sources holds promise for cell
replacement therapies for diabetes. Although most effort has focused on generating …

Mice exposed to continuous light undergo functional and histological changes that mimic
those of human Polycystic Ovary Syndrome (PCOS). We herein induced the syndrome by …