Amyloid-β (Aβ) and tau proteins currently represent the two most promising targets to treat
Alzheimer's disease. The most extensively developed method to treat the pathologic forms of …

▪ Abstract The energy landscape theory of protein folding is a statistical description of a
protein's potential surface. It assumes that folding occurs through organizing an ensemble of …

Nature exploits self‐organization of soft materials in many ways, to produce cell membranes,
biopolymer fibers and viruses, to name just three. Mankind is now able to design materials at …

Biomolecules are the prime information processing elements of living matter. Most of these
inanimate systems are polymers that compute their own structures and dynamics using as …

An elementary statistical mechanical model was used to calculate the folding rates for 22
proteins from their known three-dimensional structures. In this model, residues come into …

Protein folding has been viewed as a difficult problem of molecular self-organization. The
search problem involved in folding however has been simplified through the evolution of …

1. Introduction 22. The macroscopic and microscopic views of protein folding 22.1 The
macroscopic view: the experimental folding free-energy profile 22.2 The microscopic view …

The folding thermodynamics and kinetics of the Pin WW domain, a three-stranded
antiparallel β-sheet, have been characterized extensively. Folding and activation free …

Protein folding has become one of the most actively studied problems in modern molecular
biophysics. Approaches to the problem combine ideas from the physics of disordered …

Publisher Summary This chapter presents an overview of the theoretical aspects of the “new
view” of protein folding based on the energy landscape theory and the funnel concept. The …