Emerging evidence for astrocyte dysfunction in schizophrenia
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …
and neurobiological background influences early brain development, and whose precise …
Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects
SH Shahcheraghi, F Salemi, S Small… - Phytotherapy …, 2023 - Wiley Online Library
Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids
can experience auxiliary injury by oxidative responses. This damage produced by reactive …
can experience auxiliary injury by oxidative responses. This damage produced by reactive …
[HTML][HTML] Brain incoming call from glia during neuroinflammation: Roles of extracellular vesicles
The functionality of the central nervous system (CNS) relies on the connection, integration,
and the exchange of information among neural cells. The crosstalk among glial cells and …
and the exchange of information among neural cells. The crosstalk among glial cells and …
The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer's disease
YG Wu, LJ Song, LJ Yin, JJ Yin, Q Wang… - Neural Regeneration …, 2023 - journals.lww.com
Microglia are resident immune cells in the central nervous system. During the pathogenesis
of Alzheimer's disease, stimulatory factors continuously act on the microglia causing …
of Alzheimer's disease, stimulatory factors continuously act on the microglia causing …
[HTML][HTML] Alzheimer's Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)
A Toledano, A Rodríguez-Casado, MI Älvarez… - Brain Sciences, 2024 - mdpi.com
Background/Objectives. Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are
pathologies that affect millions of people worldwide. They have no effective therapy and are …
pathologies that affect millions of people worldwide. They have no effective therapy and are …
Pharmacological targeting of microglia dynamics in Alzheimer's disease: Preclinical and clinical evidence
A Yousefizadeh, G Piccioni, A Saidi, V Triaca… - Pharmacological …, 2022 - Elsevier
Numerous clinical trials of anti‐amyloid agents for Alzheimer's disease (AD) were so far
unsuccessful thereby challenging the validity of the amyloid hypothesis. This lack of …
unsuccessful thereby challenging the validity of the amyloid hypothesis. This lack of …
Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases
YM Ma, L Zhao - Behavioural Neurology, 2023 - Wiley Online Library
MicroRNAs (miRNAs) are the smallest class of noncoding RNAs, which widely exist in
animals and plants. They can inhibit translation or overexpression by combining with mRNA …
animals and plants. They can inhibit translation or overexpression by combining with mRNA …
N-acetylaspartate mitigates pro-inflammatory responses in microglial cells by intersecting lipid metabolism and acetylation processes
F Felice, P De Falco, M Milani, S Castelli… - Cell Communication and …, 2024 - Springer
Background Microglia play a crucial role in brain development and repair by facilitating
processes such as synaptic pruning and debris clearance. They can be activated in …
processes such as synaptic pruning and debris clearance. They can be activated in …
A mathematical model for on-target off-tumor effect of CAR-T cells on gliomas
DS Santurio, LRC Barros - Frontiers in Systems Biology, 2022 - frontiersin.org
CAR-T cell immunotherapy involves genetically reprogrammed T-lymphocytes that interact
with cancer cells and activate an anti-tumor immune response. This therapy has been …
with cancer cells and activate an anti-tumor immune response. This therapy has been …
Alzheimer's Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)
A Toledano Gasca, A Rodríguez-Casado, MI Álvarez… - 2024 - digital.csic.es
Background/Objectives. Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are
pathologies that affect millions of people worldwide. They have no effective therapy and are …
pathologies that affect millions of people worldwide. They have no effective therapy and are …