Glutamate and GABA in microglia-neuron cross-talk in Alzheimer's disease
GA Czapski, JB Strosznajder - International Journal of Molecular Sciences, 2021 - mdpi.com
The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …
Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
MW Weiner, DP Veitch, PS Aisen, LA Beckett… - Alzheimer's & …, 2017 - Elsevier
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued
development and standardization of methodologies for biomarkers and has provided an …
development and standardization of methodologies for biomarkers and has provided an …
Understanding Alzheimer disease at the interface between genetics and transcriptomics
J Verheijen, K Sleegers - Trends in Genetics, 2018 - cell.com
Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …
common neurodegenerative dementia. However, mechanistic insights and improved …
A decade in psychiatric GWAS research
After more than 10 years of accumulated efforts, genome-wide association studies (GWAS)
have led to many findings, most of which have been deposited into the GWAS Catalog …
have led to many findings, most of which have been deposited into the GWAS Catalog …
Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks
AM Hossini, M Megges, A Prigione, B Lichtner… - BMC genomics, 2015 - Springer
Background Alzheimer's disease (AD) is a complex, irreversible neurodegenerative
disorder. At present there are neither reliable markers to diagnose AD at an early stage nor …
disorder. At present there are neither reliable markers to diagnose AD at an early stage nor …
Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease
W Qiu, X Guo, X Lin, Q Yang, W Zhang, Y Zhang… - Neurobiology of …, 2017 - Elsevier
Discovered in the brains of multiple animal species, piRNAs may contribute to the
pathogenesis of neuropsychiatric illnesses. The present study aimed to identify brain …
pathogenesis of neuropsychiatric illnesses. The present study aimed to identify brain …
Common factors in neurodegeneration: a meta-study revealing shared patterns on a multi-omics scale
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) are heterogeneous …
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) are heterogeneous …
Evolutionary and functional impact of common polymorphic inversions in the human genome
C Giner-Delgado, S Villatoro, J Lerga-Jaso… - Nature …, 2019 - nature.com
Inversions are one type of structural variants linked to phenotypic differences and adaptation
in multiple organisms. However, there is still very little information about polymorphic …
in multiple organisms. However, there is still very little information about polymorphic …
An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission
Alzheimer's disease (AD) is a progressive neurodegenerative disease. The accumulation of
amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the key players responsible for …
amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the key players responsible for …
An inside job: how endosomal Na+/H+ exchangers link to autism and neurological disease
Autism imposes a major impediment to childhood development and a huge emotional and
financial burden on society. In recent years, there has been rapidly accumulating genetic …
financial burden on society. In recent years, there has been rapidly accumulating genetic …