Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Many cancers possess an incorrect number of chromosomes, a state described as
aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of …

Errors in chromosome segregation during mitosis have been recognized as a hallmark of
tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic …

Chromosomal instability (CIN) is a hallmark of cancer that drives tumour evolution. It is now
recognised that CIN in cancer leads to the constitutive production of misplaced DNA in the …

Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype.
Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor …

Microtubule-targeted agents are commonly used for cancer treatment, though many patients
do not benefit. Microtubule-targeted drugs were assumed to elicit anticancer activity via …

The incidence of liver cancer has increased in recent years. Worldwide, liver cancer is
common: more than 600000 related deaths are estimated each year. In the USA, about …