Stress-induced mental health disorders are affecting many people around the world.
However, effective drug therapy for curing psychiatric diseases does not occur sufficiently …

Coordinated cochaperone interactions with Hsp90 and associated client proteins are crucial
for a multitude of signaling pathways in normal physiology, as well as in disease settings …

The recent discovery of activator compounds binding to an allosteric site on the NAD+-
dependent protein lysine deacetylase, sirtuin 6 (SIRT6) has attracted interest and presents a …

Background Neuropathic pain is experienced worldwide by patients suffering from nerve
injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options …

Methyl groups can have profound effects in drug discovery but the underlying mechanisms
are diverse and incompletely understood. Here we report the stereospecific effect of a …

The FK506-binding protein 51 (FKBP51) emerged as a key player in several diseases like
stress-related disorders, chronic pain, and obesity. Linear analogues of FK506 called SAFit …

Subtype selectivity represents a challenge in many drug discovery campaigns. A typical
example is the FK506 binding protein 51 (FKBP51), which has emerged as an attractive …

Members of the FK506-binding protein (FKBP) family regulate a range of important
physiological processes. Unfortunately, current therapeutics such as FK506 and rapamycin …

Amylomaltases (AMs) play important roles in glycogen and maltose metabolism. However,
the molecular mechanism is elusive. Here, we investigated the conformational dynamics of …

Abstract FK506‐binding proteins (FKBPs) are promising targets for a variety of disorders and
infectious diseases. High FKBP occupancy is thought to be necessary for ligands to …