The developmental origins of the metabolic syndrome

PD Gluckman, MA Hanson - Trends in Endocrinology & Metabolism, 2004 - cell.com
Both epidemiological and clinical evidence suggest relationships between the antenatal
environment and the risk of developing insulin resistance and associated cardiovascular …

Developmental origins of disease paradigm: a mechanistic and evolutionary perspective

PD Gluckman, MA Hanson - Pediatric research, 2004 - nature.com
Fetal growth is determined by the interaction between the environment and the fetal
genome. The fetal environment, in turn, is determined by the maternal environment and by …

Maternal constraint of fetal growth and its consequences

PD Gluckman, MA Hanson - Seminars in fetal and neonatal medicine, 2004 - Elsevier
The major non-genetic factor determining the size of the fetus at term is maternal constraint.
This term refers to a set of poorly defined processes by which maternal and uteroplacental …

Fetal growth and placental function

MK Bauer, JE Harding, NS Bassett, BH Breier… - Molecular and cellular …, 1998 - Elsevier
Fetal growth is largely determined by the availability of nutrients to the fetus. The fetus is at
the end of a supply line that ensures delivery of nutrients from the maternal/uterine …

A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between …

M Chellakooty, K Vangsgaard, T Larsen… - The Journal of …, 2004 - academic.oup.com
The aim of the study was 1) to evaluate the association of maternal serum levels of placental
GH and IGF-I with fetal growth, and 2) to establish reference data for placental GH, IGF-I, and …

Morphology and morphometry of in vivo-and in vitro-produced bovine concepti from early pregnancy to term and association with high birth weights

M Bertolini, JB Mason, SW Beam, GF Carneiro… - Theriogenology, 2002 - Elsevier
This study was designed to characterize conceptus development based on pre-and
postnatal measurements of in vivo-and in vitro-derived bovine pregnancies. In vivo …

Origins of fetal growth restriction

JS Robinson, VM Moore, JA Owens… - European Journal of …, 2000 - Elsevier
Regulation of growth of the fetus and its placenta begins before pregnancy. Early in
pregnancy the mother sets the rate of growth of the fetus on a trajectory, which may be …

The neglected role of insulin‐like growth factors in the maternal circulation regulating fetal growth

AN Sferruzzi‐Perri, JA Owens… - The Journal of …, 2011 - Wiley Online Library
Maternal insulin‐like growth factors (IGFs) play a pivotal role in modulating fetal growth via
their actions on both the mother and the placenta. Circulating IGFs influence maternal tissue …

The growth hormone–insulin-like growth factor axis in pregnancy

H Kaur, BS Muhlhausler, CT Roberts… - Journal of …, 2021 - joe.bioscientifica.com
The growth hormone (GH)–insulin-like growth factor (IGF) axis is one of the main drivers of
mammalian growth and development. Pituitary secretion of GH is pulsatile and under …

Growth factors for the treatment of ischemic brain injury (growth factor treatment)

A Larpthaveesarp, DM Ferriero, FF Gonzalez - Brain sciences, 2015 - mdpi.com
In recent years, growth factor therapy has emerged as a potential treatment for ischemic
brain injury. The efficacy of therapies that either directly introduce or stimulate local …