It has long been appreciated that the Gram-negative outer membrane acts as a permeability
barrier, but recent studies have uncovered a more expansive and versatile role for the outer …

Bacteria surround their cell membrane with a net-like peptidoglycan layer, called sacculus,
to protect the cell from bursting and maintain its cell shape. Sacculus growth during …

Most bacteria are surrounded by a peptidoglycan cell wall that defines their shape and
protects them from osmotic lysis. The expansion and division of this structure therefore plays …

The peptidoglycan (PG) cell wall is an extra-cytoplasmic glycopeptide polymeric structure
that protects bacteria from osmotic lysis and determines cellular shape. Since the cell wall …

Bacteria must divide to increase in number and colonize their niche. Binary fission is the
most widespread means of bacterial cell division, but even this relatively simple mechanism …

The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …

Antibiotic resistance among pathogenic bacteria is an ever-increasing issue worldwide.
Unfortunately, very little has been achieved in the pharmaceutical industry to combat this …

Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan
layer are crucial for the maintenance of cellular integrity and enable survival in challenging …

Recent developments in high-throughput reverse genetics, have revolutionized our ability to
map gene function and interactions,,–. The power of these approaches depends on their …

Antimicrobial peptides (AMPs) have been proposed as a novel class of antimicrobials that
could aid the fight against antibiotic resistant bacteria. The mode of action of AMPs as acting …