Paracetamol (acetaminophen) is the most commonly used drug in the world, with a long
record of use in acute and chronic pain. In recent years, the benefits of paracetamol use in …

The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many
normal physiological functions and the pathophysiology of several diseases. Since the …

Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

Background and Purpose The mechanosensitive Piezo1 channel has important roles in
vascular physiology and disease. Yoda1 is a small‐molecule agonist, but the pharmacology …

Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

Substantial experimental evidences support the hypothesis that dietary flavonoid intake has
a favourable impact on cardiovascular diseases such as systemic, arterial hypertension and …

Background and Purpose Cannabichromene (CBC) is one of the most abundant
phytocannabinoids in Cannabis spp. It has modest antinociceptive and anti‐inflammatory …

The motor symptoms of Parkinson's disease (PD) mainly arise from degeneration of
dopamine neurons within the substantia nigra. As no disease-modifying PD therapies are …

Ion channels allow the flux of specific ions across biological membranes, thereby
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …

Background and Purpose Maresin 1 (MaR1) is a specialised pro‐resolving lipid mediator
with anti‐inflammatory and analgesic activities. In this study, we addressed the modulation …