Conspectus Difluoroalkylated compounds play a remarkably important role in life and
materials sciences because of the unique characteristics of the difluoromethylene (CF2) …

Transition-metal-mediated fluoroalkylation is a hot research topic in current organofluorine
chemistry. In the past five years, due to the development of new perfluoroalkylation reagents …

Fluorine chemistry is a field undergoing tremendous expansion. Although much attention
has been paid to the introduction of the fluorine atom and the CF3 group, less interest has …

Transition‐metal‐catalyzed difluoroalkylation of aromatics remains challenging despite the
importance of difluoroalkylated arenes in medicinal chemistry. Herein, the first successful …

For almost 40 years, difluoromethylene phosphonates have proven to be versatile molecular
tools in biochemical studies owing to their close resemblance to naturally occurring …

The first example of nickel‐catalyzed decarboxylative fluoroalkylation of α, β‐unsaturated
carboxylic acids has been developed with commonly available fluoroalkyl halides. This …

A visible light-promoted difluoroalkylation reaction of arenes or heterocycles, using triaryl
phosphine as the catalyst and difluoroalkyl iodide as the alkylating agent, is presented. The …

A general and efficient access to aryl, heteroaryl, vinyl and alkynyl
difluoromethylphosphonates is described. The developed methodology using TMSCF2PO …

A mild, versatile and efficient method for the silver (I)-catalyzed oxidative decarboxylative
gem-difluoromethylenation has been developed. The radical cascade reaction comprises …

One way to introduce fluorine into a molecule is through fluoroalkylation reactions.
Transition-metal catalysts play an increasing role in selectively incorporating fluoroalkyl …