Endowed with unparalleled high catalytic activity and selectivity, enzymes offer enormous
potential as catalysts in practical applications. These applications, however, are seriously …

The long-recognized promise of gene therapy to treat a broad range of currently incurable
diseases remains largely unfulfilled, hindered by lack of a safe and efficient delivery vehicle …

Chitosan, a cationic biopolymer derived from chitin, has been described as having
antibacterial activity. The modes of this activity, however, have not been established. One …

Polyelectrolyte complexes formed between DNA and chitosan present different and
interesting physicochemical properties combined with high biocompatibility; they are very …

Hyaluronic acid (HA) has been described as a biocompatibility enhancer for gene delivery
systems; however, the mechanistic implications of its inclusion on the formation and activity …

Chitosan nanoparticles have attracted considerable attention as a potential carrier for food
and pharmaceutical applications. Herein, using natural sodium phytate as a gelation agent …

Up to now, chitosan and DNA have been investigated for gene delivery due to chitosan
advantages. It is recognized that chitosan is a biocompatible and biodegradable non-viral …

Porous and degradable hyaluronic acid (HA) microparticles was synthesized in a single step
using different ratio of crosslinker, divinylsulfone (DVS) ranging between 2.5 and 100% mole …

The encapsulation of DNA inside nanoparticles meant for gene delivery applications is a
challenging process where several parameters need to be modulated in order to design …

The design of biocompatible polyelectrolyte complexes is a promising strategy for in vivo
delivery of biologically active macromolecules. Particularly, the condensation of DNA by …