Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …

Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …

Gout is a disease caused by uric acid (UA) accumulation in the joints, causing inflammation.
Two UA forms–monosodium urate (MSU) and soluble uric acid (sUA) have been shown to …

Changes in lifestyle induce an increase in patients with hyperuricemia (HUA), leading to
gout, gouty arthritis, renal damage, and cardiovascular injury. There is a strong inflammatory …

Background Since its discovery, NLRP3 is almost never separated from its major role in the
protein complex it forms with ASC, NEK7 and Caspase-1, the inflammasome. This key …

Background Innate immunity plays a fundamental role in solid organ transplantation.
Myeloid cells can sense danger signals or DAMPs released after tissue or cell damage …

Nod-like receptors (NLRs) are innate immune receptors that play a key role in sensing
components from pathogens and from damaged cells or organelles. NLRs form signaling …

Purpose Serum uric acid (UA) not only affects the development of obesity but also alters the
metabolic status in obese subjects; thus we investigated the relationship between serum UA …

Background: Gout is a common arthritis, due to deposition of monosodium urate (MSU)
crystals which results in IL-1β secretion by tissue-resident macrophages. Xanthine oxidase …

Background The joint association of hyperuricemia and chronic kidney disease (CKD) with
mortality in patients with chronic heart failure (CHF) is not conclusive. Methods This …