Organophosphorus compounds as chemical warfare agents: a review
RT Delfino, TS Ribeiro… - Journal of the Brazilian …, 2009 - SciELO Brasil
Chemical warfare agents constitute one of the greatest threats in the modern world. Among
them, the neurotoxic agents are of special interest due to their high lethality and danger …
them, the neurotoxic agents are of special interest due to their high lethality and danger …
Counteracting poisoning with chemical warfare nerve agents
N Maček Hrvat, Z Kovarik - Arhiv za higijenu rada i toksikologiju, 2020 - hrcak.srce.hr
Sažetak Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents
(NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter …
(NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter …
Design, evaluation and structure—Activity relationship studies of the AChE reactivators against organophosphorus pesticides
Organophosphate pesticides (OPPs; eg chlorpyrifos, diazinon, paraoxon) are a wide and
heterogeneous group of organophosphorus compounds. Their biological activity of …
heterogeneous group of organophosphorus compounds. Their biological activity of …
Mini review on blood–brain barrier penetration of pyridinium aldoximes
H Kalász, SM Nurulain, G Veress… - Journal of Applied …, 2015 - Wiley Online Library
This paper reviews the blood–brain barrier (BBB) penetration of newly developed pyridinium
aldoximes. Pyridinium aldoximes are highly charged hydrophilic compounds used in the …
aldoximes. Pyridinium aldoximes are highly charged hydrophilic compounds used in the …
The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives
The first organophosphorus nerve agent was discovered accidently during the development
of pesticides, shortly after the first use of chemical weapons (chlorine, phosgene) on the …
of pesticides, shortly after the first use of chemical weapons (chlorine, phosgene) on the …
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun …
The potency of newly developed monoxime bispyridinium compounds (K156, K203) in
reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic …
reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic …
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1, 3-diyl linkage—Preparation, in vitro screening and molecular docking
The treatment of organophosphorus (OP) poisoning consists of the administration of a
parasympatholytic agent (eg, atropine), an anticonvulsant (eg, diazepam) and an …
parasympatholytic agent (eg, atropine), an anticonvulsant (eg, diazepam) and an …
The effect of neutral oximes on the reactivation of human acetylcholinesterase inhibited with paraoxon
TS Ribeiro, A Prates, SR Alves… - Journal of the Brazilian …, 2012 - SciELO Brasil
Important defense agents against chemical warfare weapons, which are reactivators of
human acetylcholinesterase (huAChE) inhibited by neurotoxic organophosphorus …
human acetylcholinesterase (huAChE) inhibited by neurotoxic organophosphorus …
Novel group of AChE reactivators—synthesis, in vitro reactivation and molecular docking study
The acetylcholinesterase (AChE) reactivators (eg, obidoxime, asoxime) became an
essential part of organophosphorus (OP) poisoning treatment, together with atropine and …
essential part of organophosphorus (OP) poisoning treatment, together with atropine and …
Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage—initial study for Myasthenia gravis …
Reversible inhibitors (eg, pyridostigmine bromide, neostigmine bromide) of carbamate origin
are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase …
are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase …