Owing to their tunable properties, controllable degradation, and ability to protect labile
drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a …

The current achievements in treating glioblastoma (GBM) patients are not sufficient because
many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem …

Noncovalent forces are of considerable importance in the formation of self-assembled drug-
delivery systems. In addition to non-destructively linking the delivery vehicle and guest drug …

Hydrogels are water-swollen three-dimensional networks made of polymers, proteins, small
molecules or colloids. They constitute a versatile platform for drug delivery because of their …

The central nervous system (CNS), consisting of the brain, spinal cord, and retina,
superintends to the acquisition, integration and processing of peripheral information to …

Glioblastoma (GBM) is one of the most aggressive and deadliest central nervous system
tumors, and the current standard treatment is surgery followed by radiotherapy with …

Surgery remains a primary modality of treatment for the majority of solid tumor malignancies.
While advancements in surgical technique and instrumentation have improved the quality of …

Many biomaterials have been developed which aim to match the elastic modulus of the
brain for improved interfacing. However, other properties such as ultimate toughness, tensile …

Glioblastoma (GBM) is a particularly aggressive brain cancer associated with high
recurrence and poor prognosis. The standard of care, surgical resection followed by …

The central nervous system (CNS) controls the acquisition and processing of peripheral
information to manage the behaviors of organisms. CNS disorders, including CNS injuries …