Glutathione in brain disorders and aging
IY Iskusnykh, AA Zakharova, D Pathak - Molecules, 2022 - mdpi.com
Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …
[HTML][HTML] Neuropathic pain: delving into the oxidative origin and the possible implication of transient receptor potential channels
C Carrasco, M Naziroǧlu, AB Rodríguez… - Frontiers in …, 2018 - frontiersin.org
Currently, neuropathic pain is an underestimated socioeconomic health problem affecting
millions of people worldwide, which incidence may increase in the next years due to …
millions of people worldwide, which incidence may increase in the next years due to …
TRPM2: a candidate therapeutic target for treating neurological diseases
JC Belrose, MF Jackson - Acta Pharmacologica Sinica, 2018 - nature.com
Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca 2+)-permeable non-
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …
The G protein–coupled receptor–transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation
Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …
Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in …
K Yıldızhan, M Nazıroğlu - Molecular neurobiology, 2020 - Springer
Parkinson's disease (PD) is one of most common neurodegenerative diseases.
Environmental stressors such as oxidative stress (OS), calcium ion influx, apoptosis, and …
Environmental stressors such as oxidative stress (OS), calcium ion influx, apoptosis, and …
Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement …
IS Övey, M Naziroğlu - Neuroscience, 2015 - Elsevier
Oxidative stress and apoptosis were induced in neuronal cultures by inhibition of glutathione
(GSH) biosynthesis with d, l-buthionine-S, R-sulfoximine (BSO). Transient receptor potential …
(GSH) biosynthesis with d, l-buthionine-S, R-sulfoximine (BSO). Transient receptor potential …
Photosensitization in porphyrias and photodynamic therapy involves TRPA1 and TRPV1
A Babes, SK Sauer, L Moparthi, TI Kichko… - Journal of …, 2016 - Soc Neuroscience
Photosensitization, an exaggerated sensitivity to harmless light, occurs genetically in rare
diseases, such as porphyrias, and in photodynamic therapy where short-term toxicity is …
diseases, such as porphyrias, and in photodynamic therapy where short-term toxicity is …
Involvement of TRPM2 in the neurobiology of experimental migraine: focus on oxidative stress and apoptosis
Y Yazğan, M Nazıroğlu - Molecular Neurobiology, 2021 - Springer
Excessive Ca2+ influx and mitochondrial oxidative stress (OS) of trigeminal ganglia (TG)
have essential roles in the etiology of migraine headache and aura. The stimulation of …
have essential roles in the etiology of migraine headache and aura. The stimulation of …
Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans
The transient receptor potential melastatin (TRPM) protein family is an extensive group of
ion channels expressed in several types of mammalian cells. Many studies have shown that …
ion channels expressed in several types of mammalian cells. Many studies have shown that …
Effects of selenium on calcium signaling and apoptosis in rat dorsal root ganglion neurons induced by oxidative stress
AC Uğuz, M Nazıroğlu - Neurochemical research, 2012 - Springer
Ca 2+ is well known for its role as crucial second messenger in modulating many cellular
physiological functions, Ca 2+ overload is detrimental to cellular function and may present …
physiological functions, Ca 2+ overload is detrimental to cellular function and may present …