Animal models play an indispensable role in the study of human diseases. However, animal
models of different diseases do not fully mimic the complex internal environment of humans …

Understanding of autoimmune diseases, including multiple sclerosis, has expanded
considerably in recent years. New insights have been provided by not only animal models …

Monoallelic point mutations of isocitrate dehydrogenase type 1 (IDH1) are an early and
defining event in the development of a subgroup of gliomas,, and other types of tumour …

Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging
neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile …

Rheumatoid arthritis (RA) is genetically associated with MHC class II molecules that contain
the shared epitope. These MHC molecules may participate in disease pathogenesis by …

Rheumatoid arthritis (RA)-associated IgG antibodies such as anti-citrullinated protein
antibodies (ACPAs) have diverse glycosylation variants; however, key sugar chains …

MHC class II (MHC-II) molecules play a central role in the selection of the T cell repertoire, in
the establishment and regulation of the adaptive immune response, and in autoimmune …

Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface
protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major …

Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and
Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a …

Rheumatoid arthritis (RA) is a common autoimmune disease that afflicts the synovium of
diarthrodial joints. The pathogenic mechanisms inciting this disease are not fully …