Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient

L Jaki, S Weigang, L Kern, S Kramme… - Nature …, 2023 - nature.com
Monoclonal antibodies (mAbs) directed against the spike of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) are effective therapeutic options to combat …

[HTML][HTML] Persistent SARS-CoV-2–specific immune defects in kidney transplant recipients following third mRNA vaccine dose

WA Werbel, AH Karaba, TPY Chiang, AB Massie… - American Journal of …, 2023 - Elsevier
Kidney transplant recipients (KTRs) show poorer response to SARS-CoV-2 mRNA
vaccination, yet response patterns and mechanistic drivers following third doses are ill …

Measures to Increase Immunogenicity of SARS-CoV-2 Vaccines in Solid Organ Transplant Recipients: A Narrative Review

B Yu, C Tamargo, DC Brennan, S Kant - Vaccines, 2023 - mdpi.com
Purpose of review: To review the data on the immunogenicity of COVID-19 vaccines,
administered by different strategies, in solid organ transplant recipients (SOTRs). Recent …

Immune response to third SARS‐CoV‐2 vaccination in seronegative kidney transplant recipients: Possible improvement by mycophenolate mofetil reduction

M Kantauskaite, L Müller, J Hillebrandt… - Clinical …, 2022 - Wiley Online Library
Modification of vaccination strategies is necessary to improve the immune response to
SARS‐CoV‐2 vaccination in kidney transplant recipients (KTRs). This multicenter …

mTOR inhibitors, mycophenolates, and other immunosuppression regimens on antibody response to SARS‐CoV‐2 mRNA vaccines in solid organ transplant …

S Bae, JL Alejo, TPY Chiang… - American Journal of …, 2022 - Wiley Online Library
A recent study concluded that SARS‐CoV‐2 mRNA vaccine responses were improved
among transplant patients taking mTOR inhibitors (mTORi). This could have profound …

Cowpox to COVID: History of vaccination in the immunocompromised host

J Schaenman, R Avery - Transplant Infectious Disease, 2023 - Wiley Online Library
Background The use of vaccination to prevent infection has a long history, starting in the
1700s with Jenner. New innovations have led to improvements in the safety and efficacy of …

Role of mTOR inhibitor in the cellular and humoral immune response to a booster dose of SARS-CoV-2 mRNA-1273 vaccine in kidney transplant recipients

I Pérez-Flores, I Juarez, AS Aiffil Meneses… - Frontiers in …, 2023 - frontiersin.org
Background Immunocompromised patients have an increased risk of developing severe
COVID disease, as well as a tendency to suboptimal responses to vaccines. The objective of …

Predicting a positive antibody response after 2 SARS-CoV-2 mRNA vaccines in transplant recipients: a machine learning approach with external validation

JL Alejo, J Mitchell, TPY Chiang, A Chang… - …, 2022 - journals.lww.com
Background. Solid organ transplant recipients (SOTRs) are less likely to mount an antibody
response to SARS-CoV-2 mRNA vaccines. Understanding risk factors for impaired vaccine …

Predominantly defective CD8+ T cell immunity to SARS-CoV-2 mRNA vaccination in lung transplant recipients

E Taus, MY Shino, FJ Ibarrondo, MA Hausner… - Journal of translational …, 2023 - Springer
Background Although mRNA vaccines have overall efficacy preventing morbidity/mortality
from SARS-CoV-2 infection, immunocompromised persons remain at risk. Antibodies mostly …

mRNA-based COVID-19 vaccination of lung transplant recipients with prior SARS-CoV-2 infection induces durable SARS-CoV-2-specific antibodies and T cells

S Liu, LLA van Dijk, Y den Hartog, R Hoek… - Vaccine, 2024 - Elsevier
Lung transplant recipients (LTRs) are particularly at risk of developing severe coronavirus
disease-2019 (COVID-19), but are also difficult to protect by vaccination due to their …