If chronic kidney disease (CKD) is associated with an impairment of kidney function, several
uremic solutes are retained. Some of these exert toxic effects, which are called uremic …

The counterions neutralizing the charges on polyelectrolytes such as DNA or heparin may
dissociate in water and greatly influence the interaction of such polyelectrolytes with …

The presence of toxins is believed to be a major factor in the development of uremia in
patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Uremic …

As protein binding of uremic toxins is not well understood, neither in chronic kidney disease
(CKD) progression, nor during a hemodialysis (HD) session, we studied protein binding in …

Toxin retention is felt to be a major contributor to the development of uremia in patients with
advanced chronic kidney disease and end-stage renal disease (ESRD). Uremic retention …

The clinical picture of the uraemic syndrome is a complex amalgam of accelerated ageing
and organ dysfunction, which progress in parallel to chronic kidney disease. The uraemic …

In this article, we review approaches for decreasing uremic solute concentrations in chronic
kidney disease and in particular, in end-stage renal disease (ESRD). The rationale to do so …

The prevalence of chronic kidney disease (CKD) in the worldwide population is currently
estimated between 11% and 13%. Adequate renal clearance is compromised in these …

Introduction: Since the advent of peritoneal dialysis (PD) in the 1970s, the principles of
dialysis have changed little. In the coming decades, several major breakthroughs are …

We discuss recent investigations of the interaction of polyelectrolytes with proteins. In
particular, we review our recent studies on the interaction of simple proteins such as human …