Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Antibacterial fluoroquinolones (FQs) are frequently used in treating infections. However, the
value of FQs is debatable due to their association with severe adverse effects (AEs). The …

As the coronavirus disease 19 (COVID-19) global pandemic rages across the globe, the
race to prevent and treat this deadly disease has led to the “off-label” repurposing of drugs …

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

Background Long-QT syndromes are heritable diseases associated with prolongation of the
QT interval on an electrocardiogram and a high risk of sudden cardiac death due to …

however, this characteristic twisting morphology may not be evident in all ECG leads.
Second, episodes of drug-induced TdP usually start with a short-long-short pattern of RR …

Individuals with congenital or acquired prolongation of the QT interval, or long QT syndrome
(LQTS), are at risk of life-threatening ventricular arrhythmia,. LQTS is commonly genetic in …

A cardiac arrhythmia simply defined is a variation from the normal heart rate and/or rhythm
that is not physiologically justified. Recent years have witnessed important advances in our …

Background Prolongation of the corrected QT (QTc) interval is a key issue for patients who
receive psychotropic medications. Such patients may have baseline clinical risk factors for …

The prolonged QT interval is both widely seen and associated with the potentially deadly
rhythm, Torsades de Pointes (TdP). While it can occur spontaneously in the congenital form …