Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent
due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio …

Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most
abundant non-collagenous protein expressed in mineralized tissues. This review will focus …

The SPARC family of proteins represents a diverse group of proteins that modulate cell
interaction with the extracellular milieu. The eight members of the SPARC protein family are …

The implementation of mammographic screening programmes in many countries has been
linked to a marked increase in early detection and improved prognosis for breast cancer …

The family of matricellular proteins comprises molecules with disparate biology. The main
characteristic of matricellular proteins is to be expressed during tissue renewal and repair in …

Periodontitis is a chronic inflammatory condition of the tissues that surround and support the
teeth and is initiated by inappropriate and excessive immune responses to bacteria in …

Wnt/β-catenin or canonical Wnt signaling pathway regulates the self-renewal of cancer stem-
like cells (CSCs) and is involved in tumor progression and chemotherapy resistance …

Osteonectin binds strongly to type I collagen and hydroxyapatite and plays a crucial role in
extracellular matrix mineralization. Previous studies have also shown that p38 signaling …

This chapter focuses on the extracellular matrix (ECM), which is synthesized primarily by
osteo‐blasts but also contains proteins adsorbed from the circulation. The preponderance of …

The remarkable mechanical behavior of bone is attributed to its complex nanocomposite
structure that, in addition to mineral and collagen, comprises a variety of non-collagenous …