[HTML][HTML] Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures
Cyclic nucleotide-modulated channels have important roles in visual signal transduction and
pacemaking. Binding of cyclic nucleotides (cAMP/cGMP) elicits diverse functional responses …
pacemaking. Binding of cyclic nucleotides (cAMP/cGMP) elicits diverse functional responses …
Molecular mechanisms of homeostatic plasticity in central pattern generator networks
AJ Northcutt, DJ Schulz - Developmental neurobiology, 2020 - Wiley Online Library
Central pattern generator (CPG) networks rely on a balance of intrinsic and network
properties to produce reliable, repeatable activity patterns. This balance is maintained by …
properties to produce reliable, repeatable activity patterns. This balance is maintained by …
Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency
RL Joyce, NP Beyer, G Vasilopoulos, KA Woll… - Biochemical …, 2019 - Elsevier
Background and purpose In models of neuropathic pain, inhibition of HCN1 is anti-
hyperalgesic. 2, 6-di-iso-propyl phenol (propofol) and its non-anesthetic congener, 2, 6-di …
hyperalgesic. 2, 6-di-iso-propyl phenol (propofol) and its non-anesthetic congener, 2, 6-di …
The effects of neuropeptide Y on dissociated subfornical organ neurons
L Shute - 2016 - mspace.lib.umanitoba.ca
The subfornical organ (SFO) is a sensory circumventricular organ, lacking a proper blood-
brain barrier. Neurons of the SFO are exposed directly to the ionic environment and …
brain barrier. Neurons of the SFO are exposed directly to the ionic environment and …