CRISPR technology: A decade of genome editing is only the beginning
JY Wang, JA Doudna - Science, 2023 - science.org
The advent of clustered regularly interspaced short palindromic repeat (CRISPR) genome
editing, coupled with advances in computing and imaging capabilities, has initiated a new …
editing, coupled with advances in computing and imaging capabilities, has initiated a new …
Understanding 3D genome organization by multidisciplinary methods
I Jerkovic, G Cavalli - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …
function. Although 3D genome organization has been historically difficult to study owing to a …
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing
Compact and versatile CRISPR-Cas systems will enable genome engineering applications
through high-efficiency delivery in a wide variety of contexts. Here, we create an efficient …
through high-efficiency delivery in a wide variety of contexts. Here, we create an efficient …
CRISPR technologies for precise epigenome editing
The epigenome involves a complex set of cellular processes governing genomic activity.
Dissecting this complexity necessitates the development of tools capable of specifically …
Dissecting this complexity necessitates the development of tools capable of specifically …
[HTML][HTML] Development of CRISPR as an antiviral strategy to combat SARS-CoV-2 and influenza
Summary The coronavirus disease 2019 (COVID-19) pandemic, caused by the SARS-CoV-
2 virus, has highlighted the need for antiviral approaches that can target emerging viruses …
2 virus, has highlighted the need for antiviral approaches that can target emerging viruses …
CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules
W Feng, AM Newbigging, J Tao, Y Cao, H Peng… - Chemical …, 2021 - pubs.rsc.org
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-
associated (Cas) protein systems have transformed the field of genome editing and …
associated (Cas) protein systems have transformed the field of genome editing and …
Massively parallel Cas13 screens reveal principles for guide RNA design
Type VI CRISPR enzymes are RNA-targeting proteins with nuclease activity that enable
specific and robust target gene knockdown without altering the genome. To define rules for …
specific and robust target gene knockdown without altering the genome. To define rules for …
MyoD is a 3D genome structure organizer for muscle cell identity
R Wang, F Chen, Q Chen, X Wan, M Shi… - Nature …, 2022 - nature.com
The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each
cell type has a unique 3D genome organization that determines its cell identity. An …
cell type has a unique 3D genome organization that determines its cell identity. An …
DM3Loc: multi-label mRNA subcellular localization prediction and analysis based on multi-head self-attention mechanism
Subcellular localization of messenger RNAs (mRNAs), as a prevalent mechanism, gives
precise and efficient control for the translation process. There is mounting evidence for the …
precise and efficient control for the translation process. There is mounting evidence for the …
CRISPR mediated biosensing toward understanding cellular biology and point‐of‐care diagnosis
Recent advances in CRISPR based biotechnologies have greatly expanded our capabilities
to repurpose CRISPR for the development of biomolecular sensors for diagnosing diseases …
to repurpose CRISPR for the development of biomolecular sensors for diagnosing diseases …