The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

Simple Summary Pancreatic cancer is a very deadly form of cancer with a low survival rate.
One important characteristic of pancreatic cancer is the presence of a dense tissue called …

Historically believed to be a homogeneous cell type that is often overlooked, fibroblasts are
more and more understood to be heterogeneous in nature. Though the mechanisms behind …

Mechanosensitive ion channel protein 1 (Piezo1) is a large homotrimeric membrane protein.
Piezo1 has various effects and plays an important and irreplaceable role in the maintenance …

Simple Summary The rising population of people with obesity has presented an important
need for the study of how adipocytes (fat cells) behave and affect biological function …

Fibrosis is primarily described as the deposition of excessive extracellular matrix, but in
many tissues it also involves a loss of lipid or lipid‐filled cells. Lipid‐filled cells are critical to …

Skin fibrosis is a clinical problem with devastating impacts but limited treatment options. In
the setting of diabetes, insulin administration often causes local dermal fibrosis, leading to a …

Progressive fibrosis causes tissue malfunction and organ failure due to the pathologic
accumulation of a collagen-rich extracellular matrix. In vitro models provide useful tools for …