Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …

Emerging experimental evidence suggests that the spread of tau pathology in the brain in
Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …

The progressive deposition of misfolded hyperphosphorylated tau is a pathological hallmark
of tauopathies, including Alzheimer's disease. However, the underlying molecular …

The term “propagon” is used to define proteins that may transmit misfolding in vitro, in
tissues or in organisms. Among propagons, misfolded tau is thought to be involved in the …

The microtubule-associated protein tau has a critical role in Alzheimer's disease and other
tauopathies. A proposed pathomechanism in the progression of tauopathies is the trans …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

Background The trans-neuronal propagation of tau has been implicated in the progression
of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how …

Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their
vital functions, mitochondrial quality control (MQC) systems are in place to support organelle …