Metals and neuronal metal binding proteins implicated in Alzheimer's disease
JS Cristóvão, R Santos… - Oxidative medicine and …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent age‐related dementia affecting millions of
people worldwide. Its main pathological hallmark feature is the formation of insoluble protein …
people worldwide. Its main pathological hallmark feature is the formation of insoluble protein …
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation
Amyloid-β (Aβ) aggregation and neuroinflammation are consistent features in Alzheimer's
disease (AD) and strong candidates for the initiation of neurodegeneration. S100B is one of …
disease (AD) and strong candidates for the initiation of neurodegeneration. S100B is one of …
Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer's disease model mice
S Hagmeyer, MA Romão, JS Cristóvão… - Frontiers in …, 2019 - frontiersin.org
Increasing evidence links proteins of the S100 family to the pathogenesis of Alzheimer's
disease (AD). S100 proteins are EF-hand calcium-binding proteins with intra-and …
disease (AD). S100 proteins are EF-hand calcium-binding proteins with intra-and …
Zinc binding to S100B affords regulation of trace metal homeostasis and excitotoxicity in the brain
Neuronal metal ions such as zinc are essential for brain function. In particular synaptic
processes are tightly related to metal and protein homeostasis, for example through …
processes are tightly related to metal and protein homeostasis, for example through …
[HTML][HTML] Tetramerization of the S100B chaperone spawns a Ca2+ independent regulatory surface that enhances anti-aggregation activity and client specificity
Alzheimer's disease (AD) hallmarks include the aggregation of amyloid-β (Aβ), tau and
neuroinflammation promoted by several alarmins. Among these is S100B, a small astrocytic …
neuroinflammation promoted by several alarmins. Among these is S100B, a small astrocytic …
Computational analysis of the interactions between the S100B extracellular chaperone and its amyloid β peptide client
FEP Rodrigues, AJ Figueira, CM Gomes… - International Journal of …, 2021 - mdpi.com
S100B is an astrocytic extracellular Ca2+-binding protein implicated in Alzheimer's disease,
whose role as a holdase-type chaperone delaying Aβ42 aggregation and toxicity was …
whose role as a holdase-type chaperone delaying Aβ42 aggregation and toxicity was …
Targeting S100B with peptides encoding intrinsic aggregation-prone sequence segments
S100 proteins assume a diversity of oligomeric states including large order self-assemblies,
with an impact on protein structure and function. Previous work has uncovered that S100 …
with an impact on protein structure and function. Previous work has uncovered that S100 …
Preparation of amyloidogenic aggregates from EF-hand β-parvalbumin and S100 proteins
J Martínez, JS Cristovao, R Sanchez, M Gasset… - … Proteins: Methods and …, 2018 - Springer
Proteins containing EF-hand helix-loop-helix-binding motifs play essential roles in calcium
homeostasis and signaling pathways. These proteins have considerable structural and …
homeostasis and signaling pathways. These proteins have considerable structural and …