Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents
HM Zhou, JG Zhang, X Zhang, Q Li - Signal transduction and targeted …, 2021 - nature.com
Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …
contribute to tumor progression and therapy resistance. However, the underlying processes …
Overcoming endocrine resistance in breast cancer
Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype.
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …
Notch signaling in development, tissue homeostasis, and disease
C Siebel, U Lendahl - Physiological reviews, 2017 - journals.physiology.org
Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
P Sansone, C Savini, I Kurelac… - Proceedings of the …, 2017 - National Acad Sciences
The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit
from dormancy have never been investigated. Here we identified the full mitochondrial …
from dormancy have never been investigated. Here we identified the full mitochondrial …
Interrogating open issues in cancer precision medicine with patient-derived xenografts
Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new
treatments and biomarkers in oncology. PDX models are used to address clinically relevant …
treatments and biomarkers in oncology. PDX models are used to address clinically relevant …
EMT and MET: necessary or permissive for metastasis?
Epithelial‐to‐mesenchymal transition (EMT) and its reverse mesenchymal‐to‐epithelial
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …
Toward understanding cancer stem cell heterogeneity in the tumor microenvironment
The epithelial–mesenchymal transition (EMT) and cancer stem cell (CSC) formation are two
paramount processes driving tumor progression, therapy resistance, and cancer metastasis …
paramount processes driving tumor progression, therapy resistance, and cancer metastasis …
Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy
PR Dandawate, D Subramaniam, RA Jensen… - Seminars in cancer …, 2016 - Elsevier
Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of …
second leading cause of cancer-related deaths in the USA. Despite the development of …
Signaling pathways governing breast cancer stem cells behavior
K Song, M Farzaneh - Stem Cell Research & Therapy, 2021 - Springer
Breast cancer is the second common cancer and the leading cause of malignancy among
females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer …
females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer …
Breast cancer stem-like cells in drug resistance: a review of mechanisms and novel therapeutic strategies to overcome drug resistance
Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …
resistance to the available systemic therapies remains a major challenge. At the molecular …