Mobile cognition: imaging the human brain in the 'real world'

M Stangl, SL Maoz, N Suthana - Nature Reviews Neuroscience, 2023 - nature.com
Cognitive neuroscience studies in humans have enabled decades of impactful discoveries
but have primarily been limited to recording the brain activity of immobile participants in a …

Flexible electronics and devices as human–machine interfaces for medical robotics

W Heng, S Solomon, W Gao - Advanced Materials, 2022 - Wiley Online Library
Medical robots are invaluable players in non‐pharmaceutical treatment of disabilities.
Particularly, using prosthetic and rehabilitation devices with human–machine interfaces can …

First-in-human prediction of chronic pain state using intracranial neural biomarkers

P Shirvalkar, J Prosky, G Chin, P Ahmadipour… - Nature …, 2023 - nature.com
Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

T Milekovic, EM Moraud, N Macellari, C Moerman… - Nature Medicine, 2023 - nature.com
People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor
deficits that are resistant to currently available therapies. To alleviate these deficits, we …

Adaptive deep brain stimulation: From experimental evidence toward practical implementation

WJ Neumann, R Gilron, S Little… - Movement …, 2023 - Wiley Online Library
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …

[HTML][HTML] Lead-DBS v3. 0: Mapping deep brain stimulation effects to local anatomy and global networks

C Neudorfer, K Butenko, S Oxenford, N Rajamani… - Neuroimage, 2023 - Elsevier
Following its introduction in 2014 and with support of a broad international community, the
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …

Pathological pallidal beta activity in Parkinson's disease is sustained during sleep and associated with sleep disturbance

Z Yin, R Ma, Q An, Y Xu, Y Gan, G Zhu, Y Jiang… - Nature …, 2023 - nature.com
Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia.
Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive …

Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder

NR Provenza, SA Sheth, EM Dastin-van Rijn… - Nature medicine, 2021 - nature.com
Detection of neural signatures related to pathological behavioral states could enable
adaptive deep brain stimulation (DBS), a potential strategy for improving efficacy of DBS for …

Cross-frequency coupling and intelligent neuromodulation

CH Yeh, C Zhang, W Shi, MT Lo… - Cyborg and bionic …, 2023 - spj.science.org
Cross-frequency coupling (CFC) reflects (nonlinear) interactions between signals of different
frequencies. Evidence from both patient and healthy participant studies suggests that CFC …

Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …