The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease
Executive dysfunction is the most important predictor for loss of independence in dementia.
As executive function involves the coordination of distributed cerebral functions, executive …
As executive function involves the coordination of distributed cerebral functions, executive …
Interactive associations of vascular risk and β-amyloid burden with cognitive decline in clinically normal elderly individuals: findings from the Harvard Aging Brain …
JS Rabin, AP Schultz, T Hedden, A Viswanathan… - JAMA …, 2018 - jamanetwork.com
Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …
Vascular risk and β‐amyloid are synergistically associated with cortical tau
Objective Neuropathological studies have demonstrated that cerebrovascular disease and
Alzheimer disease (AD) pathology frequently co‐occur in older adults. The extent to which …
Alzheimer disease (AD) pathology frequently co‐occur in older adults. The extent to which …
Cerebral white matter free water: A sensitive biomarker of cognition and function
Objective To determine whether free water (FW) content, initially developed to correct
metrics derived from diffusion tensor imaging and recently found to be strongly associated …
metrics derived from diffusion tensor imaging and recently found to be strongly associated …
Reduced fractional anisotropy of the genu of the corpus callosum as a cerebrovascular disease marker and predictor of longitudinal cognition in MCI
S Raghavan, SA Przybelski, RI Reid… - Neurobiology of …, 2020 - Elsevier
Our goal was to evaluate the utility of diffusion tensor imaging (DTI) for predicting future
cognitive decline in mild cognitive impairment (MCI) in conjunction with Alzheimer's disease …
cognitive decline in mild cognitive impairment (MCI) in conjunction with Alzheimer's disease …
Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults
Noninvasive biomarkers of early neuronal injury may help identify cognitively normal
individuals at risk of developing Alzheimer's disease (AD). A recent diffusion-weighted …
individuals at risk of developing Alzheimer's disease (AD). A recent diffusion-weighted …
Association of white matter microstructural integrity with cognition and dementia
Late-life measures of white matter (WM) microstructural integrity may predict cognitive status,
cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered …
cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered …
Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging
A Rieckmann, KA Johnson… - Proceedings of the …, 2018 - National Acad Sciences
Age-related changes in striatal function are potentially important for predicting declining
memory performance over the adult life span. Here, we used fMRI to measure functional …
memory performance over the adult life span. Here, we used fMRI to measure functional …
Socioeconomic status, lifestyle and risk of incident dementia: a prospective cohort study of 276730 participants
YN Ou, YB Zhang, YZ Li, SY Huang, W Zhang… - Geroscience, 2024 - Springer
Healthy lifestyle might alleviate the socioeconomic inequities in health, but the extent of the
joint and interactive effects of these two factors on dementia are unclear. This study aimed to …
joint and interactive effects of these two factors on dementia are unclear. This study aimed to …